bacteria and fungi to protect school children against asthma
Bakterien und Pilze in der Country prevent asthma from air which these children are exposed. is This message is a press release of the "Ludwig-Maximilian-University Munich, uni-muenchen.de
What mechanisms play a role is still unclear, but the Researchers have already identified some germs that may be responsible for the lower risk of asthma. This result could also be the prevention of asthma in other population groups as well. "The way the treatment is still far, but we have to be at least candidates for vaccine development available,"
said Ege. (New England Journal of Medicine online, February 24, 2011)
Thursday, February 24, 2011
HERE 
our daily newsletter order + + + Asthma is one of Europe on the major chronic diseases, childhood, and asthma sufferers often suffer a lifetime from their disease. why does asthma have a special social and public health relevance. is caused the disease through a combination of genetic and environmental factors, wobei verschiedene Studien der letzten Jahre ergaben, dass Bauernkinder ein deutlich niedrigeres Asthmarisiko haben als andere Kinder. Um der Ursache dieses Phänomens auf den Grund zu gehen, untersuchten die LMU-Forscher nun Schulkinder in Bayern. Im Rahmen der beiden großen europäischen Epidemiologiestudien GABRIEL und der PARSIFAL verglichen Ege und seine Kollegen Kinder, die auf einem Bauernhof lebten, mit anderen Kindern aus denselben ländlichen Regionen, die allerdings nicht auf einem Bauernhof lebten.
Das Besondere an der neuen Untersuchung: Die Wissenschaftler beschränkten sich auf Innenräume und untersuchten den Staub aus den Kinderzimmern auf Pilze und bakterielle DNA. Im Ergebnis zeigte sich, dass sich deal peasant children in indoor environment with a lot more different microbes need than other children. Here, the nuclei appeared as a kind of environmental health monitors: The more diverse the Mikrozoo in house dust was, the lower was the risk of asthma. How these bacteria reduce the risk of asthma is still unclear. Scientists hold different explanations for conceivable. "One possibility would be that the combination of certain environmental bacteria stimulate the innate immune system and asthma favorable immune situation is prevented by"
said Ege. Another explanation could be that the discussion of various environmental microorganisms excessive colonization of the lower airways with asthma-causing germs to prevent - as in the intestine that required for a smooth function, a balanced microbial flora.
said Ege. Another explanation could be that the discussion of various environmental microorganisms excessive colonization of the lower airways with asthma-causing germs to prevent - as in the intestine that required for a smooth function, a balanced microbial flora.
Microbial diversity alone, however, probably not enough to prevent asthma. It's probably a combination of specific species that can exert a protective effect. "In the whole investigated range, there were some seeds that could be particularly valuable," said Ege, "including non-specific bacilli and staphylococci - about the nature of Staphylococcus sciuri -. And molds of the genus Eurotium" The next challenge for the Scientists now is to investigate the association between the presence of microbes in house dust and the species-specific protection against asthma - and to find the long run among the candidates the germs that are eligible for a potential vaccine.
Responsible participated in the study besides the LMU scientists and researchers at the Technical University of Munich, the universities of Besançon (France), Marseille (France), Ulm, Basel (Switzerland), Utrecht (Netherlands) and Imperial College London ( UK). The work was supported by the European Commission (GABRIEL and PARSIFAL study) and in the framework of the Collaborative Research Center SFB TR 22 of the "German Research Foundation (DFG)
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